Hofmann 重排(降解)

酰胺用溴(或氯)在碱性条件下处理转变为少一个碳原子的伯胺:

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反应机理

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反应实例

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参考文献

[1] A. W. Hofrnann. Ber., 1881, 14, 272.
[2] A. W. Hofmann, Ber., 1882, 15, 407, 752, 762 ; 1884, 17, 1406; 1885, 18, 2734.
[3] E. C. Franklin, Chem. Revs., 1934, 14, 219.
[4] E. S. Wallis and J. F. Lane, Organic Reactions, 1949, 3, 267.
[5] D. E. Applequist and J. D. Roberts, Chem. Revs., 1954, 54, 1083.
[6] V. Franzen, Reaktionsmechandsmen ,  Heidelberg, 1954, 1, 57. 
[7] L. F. Fieser and M. Fieser, Advanced Organic Chemistry, New York, 1961, p 499.