Mannich 反应

含有a-活泼氢的醛、酮与甲醛及胺(伯胺、仲胺或氨)反应，结果一个a-活泼氢被胺甲基取代，此反应又称为胺甲基化反应，所得产物称为Mannich碱。

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反应机理

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反应实例

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参考文献

[1] C. Mannich and W. Krosche, Arch. Pharm.,  250, 647 (1912)
[2] F. F. Blicke in Organic Reactions 1, 303 (1942)
[3] K. W. Merz, Pharmazie 11, 505-515 (1956)
[4] H. Hellmann and G. Optiz,  Angew. Chem., 68, 265 (1956)
[5] W. Ried and G. Keil, Ann., 605, 167 (1957)
[6] B. Reickert, Die Mannich Reaktion (Springer Verlag, Berlin, 1959)
[7] T. F. Cummins and J. R. Shelton, J. Org. Chem., 25, 419 (1960)
[8] J. C. Craig, S. R. Johns and M. Moyle, J. Org. Chem., 28, 2779 (1963)
[9] H. O. House and B. M. Trost, J. Org. Cherm., 29, 1339 (1964)